Wednesday 03.07.2024

Grote Zaal

10.15-11.45h: Parallel Session 1

Session 1: The coronary circulation during development and repair

Chairs: Rui Benedito (CNIC, Madrid, Spain) & Ferdinand le Noble (KIT, Karlsruhe, Germany)
Sponsored by NeVBO

10.15-11.35h: Bin Zhou (New York, USA); Development Origins and Mechanisms of Coronary Arteries.

10.35-10.55h: Paul Riley (Oxford, UK); The role of the Cardiac Lymphatics in Heart Repair and Regeneration.

10.55-11.15h: Eric Small (Rochester, USA); Vascular mural cell contributions to coronary blood vessel development and cardiac remodeling.

11.15-11.25h: Glaser, Simone-Franziska: Notch4 induces vascular malformation-like phenotypes in heart failure

11.25-11.35h: Kopacz, Aleksandra : Identification of defined angiocrine signals from cardiac-specific endothelial cells for induction of human myocyte maturation

11.35-11.45h: Gunawan, Felix : The cardiac endothelial tissue as a niche for hematopoietic stem and progenitor cells

Wednesday 03.07.2024

Berlage Zaal

10.15-11.45h: Parallel Session 2

Session 2: Emerging functions of non-coding RNAs in the cardiovascular system

Chairs: Stefania Nicoli (Yale, USA) & Reinier Boon (Amsterdam UMC, Netherlands)
Sponsored by the Cardio-Pulmonary Excellence Cluster (CPI), Frankfurt, Germany

10.15-11.35h: Ralf Brandes (Frankfurt, Germany);  LncRNAs controlling the endothelial phenotype.

10.35-10.55h: Andrew Baker (Maastricht/Edinburgh, NL/UK); Ex vivo delivery of non-coding RNAs to prevent pathological vascular remodelling in saphenous vein grafts.

10.35-10.55h: Lars Mägdefessel (Munich, Germany); Long non-coding RNAs for vascular cell therapy.

11.15-11.25h: Stein, Leonie : Long non-coding RNA NTRAS regulates immunomodulatory phenotypes of endothelial cells

11.25-11.35h:Tual-Chalot, Simon : Double-stranded RNA sensing links antiviral innate immunity with pulmonary endothelial barrier integrity

11.35-11.45h: Luna Buitrago, Diana : Characterising the role of microRNA-26b in vascular calcification

Wednesday 03.07.2024

Effectenbeurszaal

10.15-11.45h: Parallel Session 3

Session 3: Leukocyte – Vessel wall interactions: focus on the endothelium

Chairs: Peter Hordijk (UMC Amsterdam, Netherlands) & Sussan Nourshargh (Queen Marie, Univ. of London, UK)
Sponsored by: Swiss society of Microcirculation and Vascular Research (SSMVR)

10.15-11.35h: Dietmar Vestweber (Muenster, Germany); How VE-cadherin is targeted by mechanisms that regulate the enodtheliar barrier.

10.35-10.55h: Jaap van Buul (AMC/Sanquin, NL); The immunie modulatory role of the endothelium: With a little help from my friends.

10.55-11.15h: Britta Engelhardt (Bern, Switserland); VE-cadherin expressing meningeal fibroblasts direct T cell trafficking at CNS borders

11.15-11.25h: Park, Hongryeol: Apelin 13 breaks the immune cell route from the lung to the brain

11.25-11.35h: Hayashi Vanessa : PGE2 signaling triggers CD31-independent transendothelial migration

11.35-11.45h: Savvidou Ioanna : Endothelial-targeted CD39 as a novel treatment for acute organ injury in sepsis

Wednesday 03.07.2024

Grote Zaal

13.00-14.30h: Parallel Session 5

Session 5: Systems Biology – Single cell and Spatial transcriptomics approaches

Chairs: Minna Kaikkonen (Univ. Eastern Finland, Finland) & Sikander Hayat (Aachen, Germany)

13.00-13.20h: Jeroen Bakkers (Hubrecht, Utrecht, NL); From Fish to Mice: Investigating Heart Regeneration Pathways Through Interspecies Comparison.

13.20-13.40h: Rafael Kramann (Aachen, Germany)

13.40-14.00h: Christer Betzholtz (Uppsala, Sweden)

14.00-14.10h: Malhi, Naseeb : Endothelial-Macrophage Interactions as Unveiled by Single Cell and Spatial Transcriptomics in Diabetic Vascular Dysfunction

14.10-14.20h: Pekayvaz, Kami : b Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis

14.20-14.30h: Pauli, Jessica : Single-cell and spatially resolved transcriptome analysis reveals a novel lncRNA regulator of human atherosclerosis

Wednesday 03.07.2024

Berlage Zaal

13.00-14.30h: Parallel Session 6

Session 6: Metabolic targeting of vascular remodeling

Chairs: Jeffrey Kroon (Amsterdam UMC, Netherlands) & Katrien de Bock (ETH Zürich, Switzerland)

13.00-13.20h: Ingrid Fleming (Frankfurt, Germany); Lipid mediators in diabetic cardiovascular disease.

13.20-13.40h: Massimo Santoro (Padua, Italy); Decoding metabolic-dependent translation control in vascular cells during angiogenesis.

13.40-14.00h: Michael Potente (Berlin, Germany); Surveillance mechanisms in the vascular endothelium

14.00-14.10h: Koenen, Mascha : PRDM16-Dependent Loss of Beige Adipocytes Leads to Elevated Blood Pressure

14.10-14.20h: Tapia, Alonso : Endothelial-specific AGO1 in Islet Function and Transplant Outcomes

14.20-14.30h: Rezende , Flavia : The Omega Amidase NIT2 is a novel redox-sensitive key regulator of glutamine metabolism in endothelial cells

Wednesday 03.07.2024

Effectenbeurszaal

13.00-14.30h: Parallel Session 7

Session 7: Emerging molecular mechanisms in atherosclerosis (part 1)

Chairs: Sabine Steffens (LMU, Munich, Germany) & Menno de Winther (Amsterdam UMC, Amsterdam, Netherlands)
Sponsored by SFB1123: “Atherosclerosis-Mechanisms and Networks of Novel Therapeutic targets” (Munich, Germany)

13.00-13.20h: Christian Weber (Munich, Germany); Targeting immune cell recruitment and function in atherosclerosis

13.20-13.40h: Judith Sluimer (Maastricht, NL); Arterial fibroblast identity and function

13.40-14.00h: Ziad Mallat (Cambridg, UK); Adrenergic control of innate lymphoid cells type 2 during atherosclerotic cardiovascular disease

14.00-14.10h: Asare, Yaw : A cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation

14.10-14.20h: Karadimou, Glykeria: Myeloid PCSK6 ablation increases experimental atherosclerosis, but improves plaque stability by promoting fibrogenic IL-17, collagen deposition and smooth muscle

14.20-14.30h: Benedicto, Ignacio: Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells

Wednesday 03.07.2024

Grote Zaal

14.50-16.20h: Parallel Session 9

Session 9: Novel players and mechanisms in vascular remodeling

Chairs: Marie-Jose Goumans (Leiden University Medical Center, Netherlands) & Tetsuro Watabe (Tokyo Medical and Dental University (TMDU), Japan)

14.50-15.10h: Naoki Mochizuki (Osaka, Japan); Interplay between endocardium and myocardium for great vessel connection to heart and for coronary vessel growth from the heart

15.10-15.30h: Rui Benedito (Madrid, Spain); Vascular Single Cell Functional Genetics

15.30-15.50h: Pitulescu, Mara : Cellular and molecular mechanisms of lung artery growth

15.50-16.00h: Shapeti, Apeksha : Force-mediated endothelial recruitment and reprogramming drive CCM lesion growth

16.00-16.10h: Rianne Schoon: VE-cadherin interacts with ARVCF to modulate endothelial integrity

16.10-16.20h: Mauro Siragusa: Identification and functional characterization of endothelial cell microproteins encoded by non-canonical open reading frames

Wednesday 03.07.2024

Berlage Zaal

14.50-16.20h: Parallel Session 10

Session 10: non-coding RNA’s for (cardio)vascular therapy – Translational session

Chairs: Margreet de Vries ( LUMC, Dept. Surgery, Netherlands) & Konstantinos Stellos (Heidelberg University, Heidelberg, Germany)
Sponsored by: TRR267: “Non-coding RNA in the Cardiovascular System” (Munich, Frankfurt, Germany)

14.50-15.10h: Andrea Bähr (München, Germany); MIcroRNA therapeutics affect microcirculatory patterns in large animal models of cardiovascular disease

15.10-15.30h: Mauro Giacca (Kings College London, UK)

15.30-15.50h: Gianluigi Condorelli (Milan, Italy); NOvel epigenetic mechanisms regulating cardiac function in heart failure

15.50-16.00h: Hosen, Mohammed Rabiul Hose : Long noncoding RNA H19 is elevated in aortic valve stenosis and governs angiogenic response and valvular endothelial cell phenotypes through endothelial to mesenchymal transition

16.00-16.10h: Juni, Rio : Novel endothelial-enriched long non-coding RNA AL590004.3 (IRENE) is dysregulated in HFpEF and controls endothelial enhancement of cardiomyocyte function

16.10-16.20h: Li, Zhaolong : Long non-coding RNA LINC-PINT regulates smooth muscle cell plasticity in developing abdominal aortic aneurysms

Wednesday 03.07.2024

Effectenbeurszaal

14.50-16.20h: Parallel Session 11

Session 11: Targeting Macrophages in vascular diseases

Chairs: Brenda Kwak (University of Geneva, Switzerland) & Andrew Murphy (Baker Heart and Diabetes Institute, Monash University Australia)

14.50-15.10h: Jürgen Bernhagen (Munich, Germany); Targeting atypical macrophage chemokines in atherosclerois and metabolic disease

15.10-15.30h: Menno de Winther (AMC, NL); Redefining the cellular landscape of atherosclerosis by single cell RNAseq:lessons for macrophages

15.30-15.50h: Trian Chavakis (Dresden, Germany); Bone marrow-mediated trained immunity in inflammatory diseases and comorbidities

15.50-16.00h: Testini, Chiara: Lyve1+ macrophages contribute to vascular density and perfusion important for tissue normalization during healing of ischemic injuries

16.00-16.10h: Karam, Marie : Astrocytic defects in a brain-edema mice model underlie a recruitment of LYVE-1+PVMs essential for edema resorption.

16.10-16.20h: Germena, Giulia : Endothelial Extracellular Vesicles signaling during diabetes. Macrophages: you’ve got a mail.

Wednesday 03.07.2024

Grote Zaal & Keur Zaal

16.30-18.00h: Session 13

Poster Sesssion and presentations